The Navigator - Navigenics Blog

Genetic insights into health and wellness

All results for "Alzheimer's disease" (5)

October 20, 2008

Don’t forget your B12

Michael Nierenberg, M.D.,

Navigenics Medical Director

Posted 10:10 AM PDT

imageAs far as vitamins go, the popular belief has been that B – or B12, specifically – is for brain. Memory, cognition and brain size have all appeared to benefit from the dietary supplement.

A new study suggests, however, that vitamin B12 doesn’t slow cognitive decline in patients already diagnosed with mild to moderate Alzheimer’s disease. Symptoms did not improve in 202 patients put on high doses of the vitamin.

But don’t throw away your bottle of B vitamins just yet.

While the new study raises questions about the vitamin’s ability to treat Alzheimer’s disease, there is still a growing body of evidence indicating that it may be useful in preventing it. A number of clinical trials have determined that sufficient levels of vitamin B12 may be needed to keep the brain from shrinking and mental cognition from declining. So, it is more important than ever to make sure you’re getting enough of this nutrient.

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Categories: Alzheimer's disease, Memory, Vitamin B12

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September 25, 2008

Your brain—a smart reason to kick the habit

Michael Nierenberg, M.D.,

Navigenics Medical Director

Posted 01:45 PM PDT

imageIn one of the more famous public service announcements ever to hit American television, a man cracks open an egg, drops it into a hot frying pan and says “This is your brain on drugs. Any questions?” In another memorable segment, actress Rachael Leigh Cook smashes an egg – and the entire kitchen – with a skillet to illustrate what happens to the brain on heroin.

But what happens to the brain after many years of smoking? New research indicates the picture is no less disturbing. Smoking side effects go beyond the heart and the lungs; they go to the very core of your being—your mind.

In a study of more than 5,000 civil servants living in London, researchers determined that smoking is associated with an increased risk of poor memory. Smoking in middle age was linked not only to a significant memory deficit, but also to a decline in reasoning ability.

The concern, however, isn’t just that smokers might forget where they put their keys or glasses. The researchers noted that cognitive impairment is often a precursor to dementia.

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Categories: Alzheimer's disease, Lung cancer, Rheumatoid arthritis, Stop smoking

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September 18, 2008

Scents may reveal Alzheimer’s risk

Michael Nierenberg, M.D.,

Navigenics Medical Director

Posted 01:30 PM PDT

imageAre you at risk of developing Alzheimer’s disease? It appears your nose may know.

In a growing body of research, an inability to identify common scents has been associated with the development of mild cognitive impairment – a precursor to Alzheimer’s disease. Older adults who have difficulty identifying odors such as lemon or cinnamon are more likely to have problems with thinking, learning and memory, according to one such study by Chicago researchers.

That may sound a bit far-fetched. But scientists know that protein deposits called tangles begin to appear in a region of the brain responsible for smell before symptoms of Alzheimer’s disease manifest themselves. An inability to identify some scents has been linked to other neurological disorders, including Parkinson’s disease, and scientists are still attempting to understand why this is.

The findings are raising hopes that doctors may one day be able to administer a sort of “scratch ‘n sniff” test to gauge olfactory abilities as part of determining a person’s risk of Alzheimer’s disease.

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Categories: Alzheimer's disease, Prevention

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August 18, 2008

Don’t let this healthy catch get away

Michael Nierenberg, M.D.,

Navigenics Medical Director

Posted 09:55 AM PDT

imageAn apple a day isn’t enough anymore. Now you also need to think fish or flaxseed in your diet to help keep the doctor away. That is why Navigenics has new recommendations to encourage our members to be sure they get enough omega-3 fatty acids in their diet.

Omega-3 fatty acids aren’t snake oil, promising to cure all ills; rather, they are oils from fish or certain nuts and plants, and researchers have found strong evidence that they have many potential health benefits.

These polyunsaturated fatty acids are found primarily in fish and fish oils, but also in some plant-based oils, such as canola oil or flaxseed oil, and certain leafy green vegetables, including spinach, kale, broccoli and seaweed.  They are essential to human health, but cannot be made by the body. That is why it is so important for people to make sure they get sufficient amounts of them through diet or supplements—and to know how much they need.

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Categories: Alzheimer's disease, Crohn's disease, About Navigenics, Breast cancer, Heart attack, Heart disease, Macular degeneration, Rheumatoid arthritis

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July 31, 2008

At last, a new gene for Alzheimer’s disease

Elana Silver,

Navigenics Curation and Epidemiology Manager

Posted 09:26 AM PDT

imageIn this era of fast-moving genome research, it seems that new genes are discovered every month for common diseases like Crohn’s disease, prostate cancer, or type 2 diabetes. However, Alzheimer’s disease has stubbornly resisted giving up any more secrets to researchers – until now.

For 15 years, only one gene, APOE, has been unambiguously associated with Alzheimer’s disease, yet scientists knew that the risk variant of APOE explained only a small amount of the genetic risk for Alzheimer’s.  Now, a new study by an international team of researchers has revealed a mutation, in a newly discovered gene, that can double the risk of Alzheimer’s disease.

The researchers cracked this piece of Alzheimer’s code by turning to bioinformatics. They used the power of sophisticated math and computing to screen for genes that are expressed in certain regions of the brain and found on chromosome regions that had previously been suspected in Alzheimer’s.

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Categories: Alzheimer's disease, Genetic research

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