The Navigator - Navigenics Blog

Genetic insights into health and wellness

April 28, 2009

Why your family history isn’t enough

Julie Sevrens Lyons,

Health writer

Posted 09:33 AM PDT

imageHere at Navigenics, some of the questions people ask us frequently relate to genetic testing and family health history. Doesn’t family history provide enough health information all on its own? How do genetic test results work with family history?

The short answer is that family history is important, but it can’t provide the whole story.

Many women who develop breast cancer, for example, have no family history of the disease. And someone who lost a grandfather and a father to heart attacks is not necessarily destined to have the same fate. Your genetic makeup is very individual in some important ways, making personal genetic information a valuable addition to family history.

In addition, for many of us, family history is often incomplete or inaccurate:

  • One sibling may recall that grandma died of lymphoma, while another insists it was breast cancer that had spread to her lymph nodes.  Who is right?
  • Other families just don’t feel comfortable discussing health problems with younger generations. Your dad may have diabetes, but does not talk about it.
  • And for the millions of Americans who were adopted or created from donated sperm or eggs, knowledge of their biological parents’ medical backgrounds can be difficult – if not impossible – to come by.

Whether you know a lot or a little about your family history, genetic testing can give you a more complete picture of your genetic predispositions so that you can take control of your health future.

Navigenics assesses genetic risk for many common health conditions, including Alzheimer’s disease, breast cancer, type 2 diabetes, prostate cancer and heart attack.

For more details and answers to family history questions, see the Family History section of our website, which includes an animated slideshow on family history and genetic inheritance.

We also have some information for people who are adopted or don’t know their family history.

Have more questions on family history? Let us know by posting a comment here.

Categories: About Navigenics, Breast cancer

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6 Comments

Michael Apr 29, 2009

Great point about some family members not wanting to talk about any potential health problems—I think that’s a larger, and more significant, issue than what’s given proper credit.

gigi Apr 30, 2009

A good comparison might be: just knowing the deck of cards from which your hand is dealt does not tell you what your cards are…

Susan May 1, 2009

So, it would seem based on your article that family history and genetic testing together is really the best?  Why doesn’t Navigenics include this in your report.  This seems like the best of all possible worlds, especially since much of the same criticism can be given to genetic testing.  For example, see how the above text can be modified to plug in family history.

The short answer is that genetic testing is important, but it can’t provide the whole story.

Many people who are found to have a genetic polymorphism that indicates increased risk for disease, such as osteoporosis or osteoarthritis, may not get the disease, or their negative family history may indicate protective genetic effects not found yet or favorable lifestyle in the family that is protective. Your family history is also very individual and provides details lacking from genetic testing that are incredibly valuable.

Marsh May 4, 2009

To draw an accurate conclusion, you need to look at the comprehensive picture. Here’s a good comparison between FHx and Gene Dx:

http://www.itrunsinmyfamily.com/blog/?p=163

Navigenics May 4, 2009

Susan:

To build a personalized health picture, there are several complementary pieces to the puzzle - family history, lifestyle behaviors, environmental exposures, personal medical history, and, of course, genetic information. That is why Navigenics chose from the outset to have a staff of genetic counselors who are available to speak with each person who goes through our testing process. These genetics professionals are uniquely trained to look closely at a person’s family history, ask focused questions, and provide insight as to how think about genetic testing results in the context of family history. While the most individual and accurate means of assessing the importance of family history is to work with a genetic counselor or other qualified healthcare provider, Navigenics is currently in the process of developing additional tools to integrate these pieces of the puzzle into its web-based reports. We will be sure to let you know when these enhancements are available!

genetic cancer testing Jul 12, 2009

Breast cancer is the most common cause of cancer in women and the second most common cause of cancer death in women in the U.S. While the majority of new breast cancers are diagnosed as a result of an abnormality seen on a mammogram,

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